Search results for "Heart valve transplantation"

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Impact of T-cell-mediated immune response on xenogeneic heart valve transplantation: short-term success and mid-term failure.

2017

Objectives Allogeneic frozen cryopreserved heart valves (allografts or homografts) are commonly used in clinical practice. A major obstacle for their application is the limited availability in particular for paediatrics. Allogeneic large animal studies revealed that alternative ice-free cryopreservation (IFC) results in better matrix preservation and reduced immunogenicity. The objective of this study was to evaluate xenogeneic (porcine) compared with allogeneic (ovine) IFC heart valves in a large animal study. Methods IFC xenografts and allografts were transplanted in 12 juvenile merino sheep for 1-12 weeks. Immunohistochemistry, ex vivo computed tomography scans and transforming growth fa…

Pulmonary and Respiratory MedicinePathologymedicine.medical_specialtySwineT-Lymphocytes0206 medical engineering02 engineering and technology030204 cardiovascular system & hematologySpectrum Analysis RamanCryopreservation03 medical and health sciences0302 clinical medicineTransforming Growth Factor betaImmunopathologyTranslational ResearchMedicineAnimalsBioprosthesisImmunity CellularSheepbiologybusiness.industryImmunogenicityGeneral MedicineTransforming growth factor beta020601 biomedical engineeringHeart ValvesTransplantationHeart valve transplantationHeart Valve Prosthesisbiology.proteinSurgeryCardiology and Cardiovascular MedicinebusinessTomography X-Ray ComputedElastinEx vivoEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

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